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Edward Plum
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| Joined: | Mon Oct 10th, 2011 |
| Location: | Neuss, Germany |
| Posts: | 31 |
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Posted: Tue Aug 14th, 2012 11:45 |
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Hello,
it is my understanding that when you take the regular dosage of Olmesartan which is 4 x 40 mg every 6 hours and for some reason you miss one interval and exceed this by 2 hours you lose the blockade. In other words if you extend the time from one interval to the next from 6 to 8 hours or even beyond you run the risk of losing the blockade effect of Olmesartan.
What about if you are on the schedule 20 mg Olmesartan every 3 hours which is an alternative dosage and you exceed the next interval by 1 hour is there already the risk of losing the blockade? I do not really know how crucial it is with the 3 hours interval.
I would appreciate your comments.
Regards
Edward Plum
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MP started Nov.4,2011 / Lyme Disease 2008, Candida, Herpes / burning feet, blurred vision, pain /
25 D = 31.2ng/ml 1,25 D = 93.3pg/ml Oct.2011 / pre MP 25 D = 57 ng/ml Aug. 2011
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djr
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| Joined: | Sun Apr 8th, 2012 |
| Location: | United Kingdom |
| Posts: | 38 |
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Posted: Tue Aug 14th, 2012 16:14 |
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I'm still trying to work out my best dose, so I'm interested in this too. But after nearly 100 days on Olmesartan, this is what I think for me (others may be different):
- If I take 40mg every six hours I seem to always be in danger of losing the blockade, judging from my body temperature.
- At 40mg every four hours, I seem to be mostly OK and have got away at times with going up to five hours. But I still lose it sometimes - don't know why or how.
- I seem to reach my peak concentration at 75-80 minutes as I often have a low blood pressure event (dizzy etc) at this time. This has made me wonder about going to a 3 hour dose as 2x80 minutes is less than 3 hours.
I would guess that if I/you need it every 3 hours to keep up the blockade, that leaves little margin for error. Good alarms and systems necessary!
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MP May'12 (no breaks) | CFS, Depression | IBS | Probable AS
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Joyful
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| Joined: | Fri Oct 19th, 2007 |
| Location: | North America |
| Posts: | 1466 |
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Posted: Tue Aug 14th, 2012 20:12 |
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Last video broadcast has the blood concentration charts with Prof. Marshall explaining...
http://marshallprotocol.com/conferences/
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Cynthia Schnitz
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| Joined: | Tue Jul 29th, 2008 |
| Location: | USA |
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Posted: Wed Aug 15th, 2012 05:23 |
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Often the symptoms are enough to remind you that you are over due. Well, I suspect that those are the symptoms that you can expect if you 'lose the blockade'. I must be a complete odd ball, as I have missed pills completely, and on rare occasions, a few hours more to boot. I have had no serious effects of this series of missed pills. More often than not, my tinnitus starts to sing much more loudly, and I am reminded I am over due, but clearly not always.
If you miss a pill by an hour or two, consider a sublingual 1/2 dose, as that takes effect in minutes, where taken by mouth it could be an hour, or an hour and a half, till the effects kick in, so the sublingual together with a normal dose should give you enough to keep the blood levels going. This could help with the 3 hour dosing being messed up, and I don't think you would have too low a blood level if you missed your 3 hour dose completely, but you certainly would want to take extra olmesartan at your next dose, then it shouldn't be any worse than 6 hour dosing.
Cynthia
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MP start 10/08 (no breaks) | Spondylitis 97, early Diverticulosis 98, early AMD 08, Calcium anomaly 95, TypeII Diabetes(?) 02 | 25D=10.1ng/ml 12/12, (preMP 125D/25D=47/43) | My progress
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Edward Plum
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| Joined: | Mon Oct 10th, 2011 |
| Location: | Neuss, Germany |
| Posts: | 31 |
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Posted: Fri Aug 17th, 2012 20:33 |
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Hello joyful,
thank you so much for giving me the link to Trevor Marshall's conference speech. Although my original question was concerning losing the blockade I found it very informative and I now know what the most effective dosage is, which is of course very valuable information. Since my start of the MP in Nov. 2011 I have been taking 40 mg Benicar every 6 hours (with the exception of recent changes to fight excessive IP) but I now will ramp it up to every 4 hours.
Sometimes knowledge comes unexpectedly.
Thanks for your help!
Edward
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MP started Nov.4,2011 / Lyme Disease 2008, Candida, Herpes / burning feet, blurred vision, pain /
25 D = 31.2ng/ml 1,25 D = 93.3pg/ml Oct.2011 / pre MP 25 D = 57 ng/ml Aug. 2011
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Edward Plum
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| Joined: | Mon Oct 10th, 2011 |
| Location: | Neuss, Germany |
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Posted: Sun Aug 19th, 2012 18:18 |
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Hello Joyful,
sorry to be a pest but I have another question:
I must admit that now I am really confused about the correct dosage for Olmesartan. After watching Trevor Marshall’s conference video from Aug. 11, 2012 I was convinced that the most effective dosage is 40 mg every 4 hours. This is what he clearly says and demonstrates in this video. He does not mention that this dosage is only for palliative purposes.
According to him the advantage of this dosage is that the maximum peak as well as the minimum base level is higher. Then I had a look at the Knowledge Base and it says that 40 mg every 6 hours is the standard dosage and the 40 mg every 4 hours is to relieve Herx reactions. The German translation states the same.
I would like to get on the most efficient dosage and wondered if you can tell me what is really correct. Up till now I have been taking the 40mg every 6 hours. Should I stay on this or ramp it up? What would be better for me?
I would appreciate an answer as I don’t really know what to do.
Regards
Edward
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MP started Nov.4,2011 / Lyme Disease 2008, Candida, Herpes / burning feet, blurred vision, pain /
25 D = 31.2ng/ml 1,25 D = 93.3pg/ml Oct.2011 / pre MP 25 D = 57 ng/ml Aug. 2011
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Frenchie
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| Joined: | Tue Aug 25th, 2009 |
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| Posts: | 186 |
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Posted: Mon Aug 20th, 2012 08:51 |
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Everybody reacts a little bit differently, and sometimes the theory doesn't quite match reality, so you will need to experiment to see what works best for you and be ready to adjust as your body progresses. If you increase to 40 mg five times per day and it makes you feel better, you can try moving up to six, if it makes you feel worse stick to four.
In my early days I was taking 40mg four times per day and when I tried to go up to six it wiped me out. Two years later I have to take 40mg six times per day to keep a lid on IP.
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Gulf War Syndrome, 1,25D 62 pg/ml Oct09, Ph1Jan10, 25D 12.9 ng/ml Nov 10
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