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MP and Th1 Discussion, Advocate Moderated > General Questions here > ** Ask your preliminary Questions in Here ** > Strange, profuse night sweats when first starting vitamin D supplementation


Strange, profuse night sweats when first starting vitamin D supplementation
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k.a.z.
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 Posted: Mon Sep 7th, 2009 01:53

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Will try to keep this short for now -  40's male in generally good physical shape & health, did (and still am) taking folic acid supplements to reduce moderate homocysteine levels.  Couple years ago nocturia developed without any BPH or other common urological cause, low testosterone eventually led to  treatment for secondary hypogonadism. 

Went to a new doctor this year who is using  more advanced treatments for secondary hypogonadism.  In addtion to new medication he wanted me to start taking D3 and work up from 1000 iu D3 every other day to 5000 iu three  times a week.

I was given D3 drops so that I could work my way up to the high dose.  I found whenever I would take 2000 iu I would end up with severe, soak anything near me sweating which would occur at night while asleep - 1000 iu had no effect.  This occured before and after I started the new treatment, and was not hormone related - had previously come off of topical TRT and know what those sweats were like - not nearly as bad.  These profuse, drenching nocturnal sweats alway correlated perfectly with days when I increased D3 supplementation level - I even stopped my other medicine for a month just to make sure the correlation was perfect.

When I got up to around two or three doses a week of 2000 iu D3 the sweating became less frequent - had 25 OH D3 tested and it was 16 ng/ml (this was at the end of a northern U.S. winter so not very surprised).  Have had low 25 OH levels in the past (e.g. ~25) but never supplmented for it.

Worked my way up to 5000 iu D3 three times a week (no sweats), plus some summer sun, and 25 OH went to the low 30s,, peaked in the low 40s and then went back down to low 30s.  Doc thought the sweats represented some clearing of some minor infection, and suggested going still higher on Vitamin D.  After two weeks at 5000 iu five days a week signficant nocturia returned (no sweats).

A bunch of searching led me to the SarcInfo and MP sites, and I read Dr. Marshall's explanation of how those with Th1 autoimmune diseases react as D3 supplmentation begins - first a worsening of sypm,to,s,. then things abate when the higher 25 OH D3 suppresses inflamation  - sorry I do not have the link handy. 

Short of stopping the five day a week D3 I am confused as to how to proceed; can I get 1,25 D tested at this juncture or would my ratio be meaningless?  My serum calcium was tested recently and was mid range IIRC.

Have a couple of other symptoms pointing to excessive vitamin D, but they are so general that they could be anything.  I did have a couple of autoimmune antibody tests run when first diagnosed with hypogonadism but would need to dig them up.

Any general advice appreciated . . . k.a.z.

Last edited on Mon Sep 7th, 2009 02:02 by k.a.z.

Rico
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 Posted: Mon Sep 7th, 2009 13:02

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You may want to read these to better understand how Vitamin D fuels chronic disease from intracellular infection:

The Truth About Vitamin D: Fourteen Reasons Why Misunderstanding Endures

Vitamin D: the alternative hypothesis

Vitamin D Discovery outpaces FDA decision making

Autoimmune disease in the era of the metagenome

Patients on the Marshall Protocol eliminate all sources of Vitamin D intake as they attempt to regain their health back.

It would be good if you had both your 25-D and 1,25-D levels measured and posted here for someone to help you interpret them. It's important that the 1,25-D sample be frozen.

D-Metabolites Tests



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Chris
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 Posted: Wed Sep 9th, 2009 21:05

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Short of stopping the five day a week D3 I am confused as to how to proceed; can I get 1,25 D tested at this juncture or would my ratio be meaningless? 


Your 1,25D level is pertinent now, as a healthy body keeps the number low.

The 1,25D levels are useful up until you start taking Benicar, and the Benicar pulls that level down.

Once you get your numbers, the MP interpretation of the D,25 and D1,25 results can be seen here:
http://mpkb.mp-dev.com/doku.php/home:tests:vitdinterpretation

You can play with the interpreter now to see what it gives for various numbers.

The ratio of 25D to 1,25D might not be so useful to you, considering the heavy supplementation.  The heavy supplementation may skew the results, but only if the 25,D is above 30 (as determined by a few sample runs through the interpreter).

If you have to heavily supplement just to get to 30 on the 25,D, my guess is that the levels of 1,25D alone will be high enough to useful.  But it's a guess from experience, not medical training.

Backing off on medically advised supplementation is not something we here can suggest.   Talk to your doctor on that.





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k.a.z.
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 Posted: Wed Dec 30th, 2009 18:46

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Rico, Chris,

Thanks for your reply a few months ago.   After conferring with my doctor he said it was ok to go off vitamin D supplementation for a few months and then get 1,25 and 25 OH tested.

Got the results back recently.  As expected 25 OH dropped back to 23 ng/ml.  Other than stopping vitamin D supplmentation there were no other dietary or sun exposure minimization steps taken.

My 1.25 (OH)2 came back at 42 pg/mL.  The sample was shipped frozen.

Using the calculator it would appear my results are inconclusive.  However, playing with the calculator you linked indicates a value of 45 pg/ml would be sufficient to indicate an elevated  1,25 level, with VDR receptor issues.

Part of the reason I'm curious is that my hypogonadism appears to be caused  by gene suppression due to a mediation I took a few years ago.  The particular genes in question lie in close vicinity to VDR.

Thanks for any input.  If it helps any I had just gotten over a cold when I had the tests run.

k.a.z,


Last edited on Wed Dec 30th, 2009 18:50 by k.a.z.

Chris
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 Posted: Wed Dec 30th, 2009 20:12

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k.a.z.,

It looks like your D numbers are such that a therapeutic trial might be considered.

Therapeutic probe (MPKB)

Night sweats - now that was an uncomfortable, smelly, tiring episode in my life.  I'm quite happy that they are long gone.

Chris



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k.a.z.
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 Posted: Sun Jan 3rd, 2010 17:47

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Is minocycline ever used as a monotherapy and/or therapeutic probe?

Thanks for the replies - k.a.z.

Deedee
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 Posted: Sun Jan 3rd, 2010 19:05

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Benicar and Vitamin D restrictions are the cornerstones of the MP, not the antibiotics.  The Benicar works to help restore your immune system, it protects organs, and it helps to lower your Vitamin D 25/1,25.  Antibiotics may come in later to help weaken bacteria, but it is the body's innate immune system that does the bacterial killing.

Antibiotics without a working immune system are not very effective, as most of us know by experience.  It is also very remarkable that once your innate immune system is working, very small amounts of antibiotics can elicit a big response. 



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