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Michael
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Posted: Fri Nov 20th, 2009 13:55 |
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Hello,
first of all: please indulge my bad english. Although I had advanced-course in school I may -better: I definately will- make mistakes in syntax or won't find the fitting words.
So, why did I sign up here?
My spouse suffers from multiple sclerosis and takes part on the MP. I began to read stuff about the MP, because I was interested in possibilities to stop her course of disease. The more we discussed about her symptoms, the more we found similarities. So she asked me to take the Vit-D-Test to find out if it's possible that I am suffering from a TH1-Inflammation, too.
Well, here are my results:
Vit-D3-25: 12,2 ng/ml
Vit-D3.1,25: 63,9 pg/ml
Seems signifikant, doesn't it? Ok, now I ask myself: should I take part in the MP, too? I like to discuss that with my partner's MP-Doctor, when she visits him in January next year (his surgery is far away from our location). So I still have time to think. I write this to you all, because I am interested in what you think about my case. Here are some informations:
I am 28 years old. In adolescence I had mood-swings, was often tired, flappable and so. In the following years these symptoms got worse, so in 2004 I went to the psychiatrist for the first time. He told me, I'd suffer from a lightly endogenous depression. I had to take meds against it for two years. This helped a little bit, besides my environment got better, so I could get off from meds in 2006. A little later I had an appendix-operation. My inflammation-values were that high, that I had to take antibiotics intravenous for a whole week. A few weeks after that my hairloss began. I still have enough hair on my head, but it became continouesly thinner until now. My mood-swings stayed beside me (they are more loyal than most people are...), but I could handle them. Nevertheless, it all got worse again, so I went to a psychologist (I didn't want to take meds again, so I prefered not to visit the psychiatrist again). Well, we've made a behavioural psychotherapy. I've learned diverse Techniques to handle with my symptoms, when they become too strong from time to time, but they haven't gone until today. Additionally since a year there is a new symptom, which I didn't know until this time: a sometimes very strong disturbance and an abstract anxiety (abstract means: I often don't really know, why I feel so anxious, but I do...).
Also I had physical symptoms during the last year: when I'm stressed out, I become dizzy, so that I sometimes have to sit down until it's gone. My right eye begans to „flicker“, and after these stressing situations I'm often tired, flappable and my mind darkens („Everything's bad! Nothing makes any sense! Everything tires and sickens!“ blah, blah, blah) Because of these physically symptoms I had several neurological tests. There were no noticeable results, except the fact, that my trigeminal nerv reacts lower than in average. The neurologist says, that's no alert.
Beside that I had following symptoms: I can't stand too bright light, I hate high temperatures, I don't like beer anymore (in younger years I drank lots of... today I prefer wine), my eyes sometimes feel like they burn (especially when I'm stressed out or emotionally down)... and, last but not least, I sometimes feel tired and agitated at the same time. This sickens me most, I guess.
When I look on my family, there are also many symptoms which eventually can be connected to TH1-Inflammation:
my father had lung-cancer (thank godness he's healty again), my mother has an anxiety disorder and low blood-pressure, my grandmother suffers from rheumatism, dementia, a light depression and had skin-cancer a few years ago, my grandpa is cardiac and hearing impared, my other grandpa died in 1992 because of lymph-gland-cancer and was a diabetic, my aunt (father's sister) suffers from a strong depression (four suicide attempts til now), another aunt (father's sister, too) has problems with her hip-joint.
I'm really not sure... does it make sense to start the MP? As I said, I want to think about it and then talk to my partner's MP-Doc. But I'm really interested in your opinions!
Regards,
Michael
Last edited on Fri Nov 20th, 2009 14:00 by Michael
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Cynthia Schnitz
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Posted: Fri Nov 20th, 2009 16:50 |
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Just a member here, but your symptoms definitely sound like TH1. Your D values are worse than mine were (47/43), and I have made terrific progress in the last year on so many things that it is mind boggling.
http://mp-lifestyles.org/forum1/100-1.html
My improvement list is near the bottom of the page and is not typical, but you sound like you are pretty functional still. How long has your wife been on the MP, and how has she progressed? Will you both be able to handle things when you go on the MP if it slows you down greatly? For some it is worse than others. For me it wasn't a particular problem. In fact, it wasn't even much noticeable to my significant other, so that he is planning to go on the MP soon, and thinks it is going to be a piece of cake. He is a doubting Thomas, but says he will be pleasantly surprised if it does affect him. Snicker, snicker.  Cynthia
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Ph1 10/08 Ph2 12/08 Ph3 6/09 125/25D 47/43 preMP 25D14 12/09 Calcium anomaly(gone?),Spondylitis,early Diverticulosis,early AMD,TypeII Diabetes(?) MyStory
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Michael
Member
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Posted: Sat Nov 21st, 2009 13:56 |
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Hello Cynthia,
thanks for your reply.
Cynthia Schnitz wrote:
How long has your wife been on the MP, and how has she progressed? Will you both be able to handle things when you go on the MP if it slows you down greatly?
My partner -we're not married- is on the MP since octobre. About her progress you can read something in her own thread ("Verena's questions")  . You're right, I am still working, there are no greater problems. She is working still, too. If the MP slows one of us down, it would be a bigger problem for her than for me, because she is a freelance lawyer with own chancellery whereas I am working as an employed remedial teacher in a big facility of the handicapped aid. This facility is affiliated to public service, which means, it wouldn't be a bigger problem for me to stay away from work for one or two weeks in case of slowed down by the MP.
Your partner thinks the MP would be a piece of cake? Errm, I disagree when I look at my partner's casually petulance (hope she won't read this  ).
Last edited on Sat Nov 21st, 2009 14:07 by Michael
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Cynthia Schnitz
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Posted: Sat Nov 21st, 2009 16:33 |
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| Sorry about not using the word partner. It is a good word even for those that are married. Think I will start using it. It is easier to type that Significant Other. Have you thought what you two will do if neither of you can drive at night for a year or more? Dr. Blaney, the most experienced of the MP doctors, on one of the videos, says that he generally asks couples which one wants to go first. Don't think that is on the internet, but on the one of the videos offered for sale/donation, LAX 2006. Reviewing it, he wants couples to be on different phases, so that one is sort of over the hump (my words) when the next one starts. Certainly, I think Verena should be far enough along to have a good idea how her experience will be, as I see she is only near the end of her first month. Cynthia
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Ph1 10/08 Ph2 12/08 Ph3 6/09 125/25D 47/43 preMP 25D14 12/09 Calcium anomaly(gone?),Spondylitis,early Diverticulosis,early AMD,TypeII Diabetes(?) MyStory
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Verena
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Posted: Sun Nov 22nd, 2009 11:56 |
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Hi Cyntia, hi all,
me and Michael just discussed his postings and realized, that he left out some symptomes, that in my opinion are quite relevant.
- his condition changes in a way, that reminds me of a kind of relapses
- from time to time he suffers from a light aphasia
- He reacts quite slow sometimes, for example, when he was a child, he had trouble catching a ball for that reason.
- The mood swings are really BAD! As far as I realize, his mood changes two or three times a day (but I am off working between 8 and 12 hours). Some time its as bad, that he seems to be a totally different person.
What I found most alarming, was, that his symptoms get worse in summer, especially at times, when we still found sunbathing a good thing to do :-(. He would get worse in the evening or on the next day. He gets a lot better in the cold. Last June, we spent a day indoor skiing, outside temperature was about 30 Celsius (hot!) and inside it was -4 Celsius, which is just below freezing temperature. We both felt way better, especially his mood was that good, that I hardly recognized him *ggg* (thats the return for "petulance").
All together, he and his symptomes reminded me a lot to my own condition a few years ago. When we received his VitD Tests, I was a little bit shocked, though, because his values where worse, than mine have been before starting Olmesartan. so actually, I think, that he is even sicker, than I am, as strange as this may sound.
Unfortunately, besides "Depression", up to now, he didn't get a proper diagnosis. The neurologial tests done in my opinion stayed quite on the surface, he was refused a MRI-scan for example. So, without something "significant" it could be hard to get Doctors in the region to cooperate...
Greetings,
Verena
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Migraine s. 1976, Eye Inflammation s. 1992, MS s. 2007, Olmesartan s. 10/09 Mino s. 03/10
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paulalbert
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Posted: Mon Nov 23rd, 2009 13:24 |
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Hi Verena,
You might be interested in this article, which is mostly on on sunshine and depression.
http://mpkb.org/doku.php/home:othertreatments:sunshine
I haven't put it in yet, but there's another interesting paper on how sunshine can trigger flares in multiple sclerosis.
So, you're not alone in this regard.
Best,
Paul
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Verena
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Posted: Mon Nov 23rd, 2009 17:55 |
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Hi Paul,
thanks a lot for the link. We just read a bit on the homepage of the German States Statistical Office at http://www.destatis.de/jetspeed/portal/cms/Sites/destatis/Internet/DE/Content/Publikationen/Querschnittsveroeffentlichungen/WirtschaftStatistik/Gesundheitswesen/AktuellSuizid,property=file.pdf
there is a study on the correlation of month and mortality by suicide (on page 10) of 2006. The results are actually significantly higher for Summer months. That does make sense!
Greetings,
Verena and Michael
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Migraine s. 1976, Eye Inflammation s. 1992, MS s. 2007, Olmesartan s. 10/09 Mino s. 03/10
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paulalbert
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Posted: Mon Nov 23rd, 2009 18:27 |
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Verena,
I don't speak Deutsch but there's a good chance the study you point to and my KB article are pointing to the same evidence. I believe the chart in the KB article is of a review.
I agree - definitely food for thought.
Paul
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Michael
Member
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Posted: Sat Jan 9th, 2010 11:52 |
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STARTED OLMESARTAN
I've met my partner's MP-doctor, discussed my symptoms and showed him my Vit-D-Test-results. He thinks, that the MP might be the right treatment for me, but he isn't so sure, because my only diagnosis so far (depression) is no proof for an TH1-Inflammation. Nevertheless, the physician thinks that we should try olmesartan for a while to find out how I feel, because my symptoms (see top of the thread) in combination with my Vit-D-Test-results are strong references for the possibility of an TH1-Inflammation at hand.
So I take olmesartan since yesterday, at first every 8 hours (my partner also started with this cycle, but had to change to every 6 hours because of IPs).
Last edited on Sat Jan 9th, 2010 12:00 by Michael
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Chris
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Posted: Mon Jan 11th, 2010 23:42 |
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Michael,
Now that you are starting the benicar, are you also avoiding light with the NOIRs, etc.?
Starting benicar can make light sensitivity a lot stronger.
Take care,
Chris
____________________
sarcoid since 1983 (or much earlier), MP since summer 2004 Chris' story
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Michael
Member
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Posted: Tue Jan 12th, 2010 15:24 |
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Hello Chris,
thank you. I know, that taking benicar can aggravate light-sensitivity. My partner started benicar (in germany it's called "olmesartan") a few months ago and has to wear NOIRs from time to time, when her light-sensitivity raises.
Myself, I don't need them until now. I always was a little bit light-sensitive, when the sun shines to bright or when, like at the moment, snow relflects it. That didn't get worse with benicar until now.
Well, I recognized some other things:
- One week ago I had an inoculation against hepatitis. On my first day of taking benicar the puncture hurted a bit, in the next few days my whole upper arm did (like a light "burning")
- On the second day my face and eyes got "hot", felt like having fever, but my body temperature was ok (don't know if this is IP, because I had those feelings many a time before starting benicar.... it's not new to me)
- On the third day my scar (appendix-operation in 2006) hurted; felt like the pain came from the inside
That's it until now.
Greetings, Michael
Last edited on Tue Jan 12th, 2010 18:05 by Michael
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Michael
Member
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Posted: Wed Jan 20th, 2010 18:05 |
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Day 12 with benicar
A few weeks before starting benicar I was without depressive symptoms. That changed today. After lunch hour I had light mood swings (for the first time since about five weeks) shortly before the next pill. A few minutes after taking it my mood returned to normal.
After work (6 p.m.) until now (8 p.m.) it feels like depression is about to return, but it doesn't come through. It's a similar feeling I had while taking "mirtazapin" (an antidepressant) which I took from 2004-2006. The difference is, "mirtazapin" didn't only prevent depression, it also reduced me quite a bit. In contrast to those days today I'm not reduced at all.
Last edited on Wed Jan 20th, 2010 20:15 by Michael
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Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Michael
Member
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Posted: Thu Mar 25th, 2010 18:56 |
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2 and a half months with olmesartan (every 8 hours)
A short status-report:
All in all, I feel good. I'm not so tired in the morning-hours like I used to be, my mood is very much more constant (less switches; and when it switches, then much softer than before), and what's completely gone is my anxiousness. Further more, the flickering of my right eye and my right forearm is gone.
Besides that, my blood-pressure is in a range from 114/60 to 99/53, depending on my activity, like before the MP.
But:
- I can't get rid of the snuffles since two weeks (I have to add, that unfortunately I have to work very much at the moment... I'm a little bit stressed out... maybe there's a link?).
- My hair loss seems to get worse. I really don't like that!!!
- Light-sensitivity increased a little (when sun is shining bright, I have to wear nOIrs)
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Michael
Member
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Posted: Fri Mar 26th, 2010 17:43 |
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Today I've started with minocycline (25mg every 2nd day). Unfortunately, the tablets don't have a "rip" in the middle, so it's nearly impossible to divide them exactly. Is this risky/questionable?
I don't want to move to 50mg until I'm really sure that my body tolerates the low 25mg-dose.
Last edited on Fri Mar 26th, 2010 18:46 by Michael
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Knochen
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Posted: Fri Mar 26th, 2010 18:37 |
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It should be fine as long as it's close. You might look for a pill splitter at the pharmacy to help.
http://commons.wikimedia.org/wiki/File ill_splitter_2.jpg
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I can help you understand the recovery process, but only your physician is licensed to give you medical care.
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Cynthia Schnitz
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Posted: Fri Mar 26th, 2010 22:24 |
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| Sometimes I find, for the flat round pills, if they are soft enough to break by hand, and Olmecip is, I get a better, more even break by hand. I just tried a 50 mg mino by hand and it broke pretty evenly. My 3 mg melatonin tablets crumble in the splitter, but break fine by hand (w/2 thumb nails in the center, index finger at each edge). Cynthia
____________________
Ph1 10/08 Ph2 12/08 Ph3 6/09 125/25D 47/43 preMP 25D14 12/09 Calcium anomaly(gone?),Spondylitis,early Diverticulosis,early AMD,TypeII Diabetes(?) MyStory
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Michael
Member
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Posted: Sat Mar 27th, 2010 17:26 |
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Thanks, Cynthia and knochen. I guess, we'll buy a splitter (Verena also started with minocycline), because the pills are really small...
Well, just took my first 25mg mino yesterday. Today we had to stay in the house most of the time, because it's a very bright day and the sun really hurts in our eyes. We both are more light-sensitive today than in the last weeks. Maybe sensitivity grows so fast? I mean, we just took a half pill mino until now...
In the house, darkened rooms, I felt quite good.
But this afternoon I had to go out to buy a birthday-present for a friend's party tonight. I was 30 minutes outside, and although I was wearing nOIrs I felt really bad (mood switched, I found it hard to talk to people, my concentration was really bad).
Now that the sun is going down (it's beginning of dawn at the moment) I can go outside without problems.
Something else:
My partner found some new moles on my back, respectively some older moles seem to grow, since I take benicar. Could there be a connection to benicar?
Also I have dandruff at the time (since one week), in combination with the fact that my hairloss gets worse.
A nice weekend to all of you,
Michael
Last edited on Sat Mar 27th, 2010 17:34 by Michael
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Sallie Q
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Posted: Sun Mar 28th, 2010 03:26 |
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Hi Michael
I have had a lot of mild mood swing, used to take antidepressants when younger. I also had some light sensitivity, not a lot by the standards of the earlier, sicker cohort of MPers.
I find I still need to be very careful to wear NoIRs outdoors, although the light does not seem so glary as in my first year on MP.
You may find the same thing, as there are two sorts of sensitivity. I still have the one where light pushes my endocrine system into trouble and I have both muscular and emotional problems which I think come through the functions of (my CWD damaged) HPA axis.
On these grounds, I would like to emphasize the benefit of being very cautious and slow in your MP journey.
Particularly as your D levels drop (this last comment applies to everyone as the D level drops into activating range).
regards
Sallie
____________________
Sjogrens; b.cancer; postviral fatigue: D25 7ng/ml@Jly10
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Michael
Member
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Posted: Thu Apr 1st, 2010 12:57 |
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Thanks, Sally. I agree and will be careful with the cruise of my MP-Treatment.
I have some other questions:
Last night I woke up from toothache in my right lower jaw. Seemed to be the two last teeth there (wisdom tooth and the one before it), further more my gingival in that area is a little swollen.
I went to the dentist and they made a radiograph, which didn't show an anomaly. The dentist says, it could be a problem with the wisdom tooth or an inflammation somewhere in the jaw. I said, it's the same pain I had a few years ago in the left lower jaw (back then they removed the wisdom tooth), but he didn't want to remove it yet, because he isn't sure what really goes on there.
Well, he wanted to give me meds into the tooth to eliminate the inflammation, but I refused that, because the meds include "Demeclocyclin" (sorry, this is just the german name, don't know the english) and I don't think that this ingredient would agree with my MP-meds (benicar and mino until now).
So, the dentist only prescribed me "Ibuprofen" (a pain reliever) and asked me to talk to my MP-doc to find out, which kind of treatment would be possible, if the inflammation / the pain doesn't stop in the next few days. Unfortunately I didn't reach him until now.
So: is there some information about the possibilities of dental treatment somewhere on the MP-sides? I'm already searching but would be thankful if someone of you could tell me of his or her own experiences.
And one more question: could my problem be IP? In the last few years before starting MP I had three times problems with inflammations in that area. They gave me antibiotics and the problem was (provisional) solved. Now I can't agree with that treatment because of my MP-meds. What could be the alternative?
Besides that I feel well although I had lots of work and too little sleep the last two days (I know, that's insensate... the next four days I'm quit of work and want to make use of this to sleep and relax ) .
Last edited on Thu Apr 1st, 2010 13:06 by Michael
____________________
Depression (dx. 2004); D-25: 12,2 ng/ml, D-1,25: 63,9 pg/ml (tested 11/2009); Benicar s. 01/2010; minocycline s. 03/2010
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Chris
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Posted: Thu Apr 1st, 2010 23:28 |
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Demeclocyclin is pretty much the same in English (Demeclocycline). It is an MP drug. It's a tetracycline, like minocycline, and similar enough to minocycline that they aren't used in combination as they target the same things.
I found it to cause stronger IP than mino, which isn't the case with every patient. But it's good to be cautious.
Jaw and tooth pain can be IP. Periodontal disease does get better with the MP. Not everything works out with the MP. I lost a molar along the way. It had a previous root canal fix, so was probably too far gone before I started the MP. I have wondered if at the end it was just held together by the biofilm bugs, and disintegrated when the MP started killing them.
http://mpkb.org/doku.php/home:special:dentist
http://mpkb.org/doku.php/home:symptoms:headandneck:dental
http://mpkb.org/doku.php/home:diseases:periodontal_disease
Chris
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sarcoid since 1983 (or much earlier), MP since summer 2004 Chris' story
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