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Question about olmesartan doseing
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JSK
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Joined: Tue Jun 30th, 2009
Location: Finland
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 Posted: Fri Nov 20th, 2009 08:41

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I was wondering why recommended dose of olmesartan is nowadays 4 x 40mg/day if immuno modulatory effect comes already with 3 x 20mg/day?

And why recommended dose was lifted from 3 x 40mg /day to 4 x 40mg /day?

Is it because of anti-imflammatory / palliative effect?
Or is immuno modulatory effect stronger with bigger doses?




____________________
Since Jan. 2009 after a flue shortness of breath etc. Chronic chpn/mypn infection. Ph.1 Oct.17.th 2009. mod.ph.2 Apr.18th 2010 Olme4x40+(M+C48h). Apr.10th-2010 25D 6,9ng/ml.
Knochen
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 Posted: Fri Nov 20th, 2009 18:45

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I believe the dosing schedule was changed because the 8 hour interval didn't leave enough "wiggle room" for taking the medication on time.  After 8 hours, the blockade can be lost, and that is not a good thing.  Putting the dose every 6 hours allows a patient to be off by an hour and still not lose the blockade.

There may have been considerations about palliative/inflammatory effects as well, but I don't believe those were the major factors in the change.



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I can help you understand the recovery process, but only your physician is licensed to give you medical care.
paulalbert
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 Posted: Sun Nov 22nd, 2009 15:01

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Knochen is right about that.

I would just like to add that the pharmacodynamics of olmesartan are such that its effects on the VDR are not exactly dose-dependent and require a relatively large one-time dose to knock off any other ligands off the Receptor.
http://mpkb.org/doku.php/home:protocol:olmesartan

Here's another article that may be useful:
http://mpkb.org/doku.php/home:mp:mpmeds:olmesartan:dosing

Best,
Paul


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