I was wondering why recommended dose of olmesartan is nowadays 4 x 40mg/day if immuno modulatory effect comes already with 3 x 20mg/day?
And why recommended dose was lifted from 3 x 40mg /day to 4 x 40mg /day?
Is it because of anti-imflammatory / palliative effect?
Or is immuno modulatory effect stronger with bigger doses?
____________________ Since jan-09 after a flue shortness of breath. Chpn+mypn chronic infection, tested July-09. Working normally. Started ph.1 17.Oct-09. Olme4x40/day. From Dec27 mino100.
I believe the dosing schedule was changed because the 8 hour interval didn't leave enough "wiggle room" for taking the medication on time. After 8 hours, the blockade can be lost, and that is not a good thing. Putting the dose every 6 hours allows a patient to be off by an hour and still not lose the blockade.
There may have been considerations about palliative/inflammatory effects as well, but I don't believe those were the major factors in the change.
____________________ I can help you understand the recovery process, but only your physician is licensed to give you medical care.
I would just like to add that the pharmacodynamics of olmesartan are such that its effects on the VDR are not exactly dose-dependent and require a relatively large one-time dose to knock off any other ligands off the Receptor. http://mpkb.org/doku.php/home:protocol:olmesartan
